Palmitoylethanolamide - a novel OPIOID tolerance reducer

[vesku88]

Interesting older post. When I use this PEA, it’s to immediately stop any kratom benefits. It blocks kratom almost instantly. For times when I use more than I shoulda, for example. I’m definitely noticing the lack of kratom benefits right away.

I hate to have to read 250 posts on this topic. Y’all are using it for weaning?

I’ll keep jumping around the topic and see if I can figure out what y’all are finding it helpful for. I usually take it at night for lower tolerance the next morning. As opposed to mixing the PEA WITH kratom. Hmmm

Wait what....PEA is not supposed to block your kratom...

PEA would likely block some of Kratom's positive effects if they are taken concurrently. However, they are NOT meant to be taken together, but rather as far apart as possible. PEA lowers opioid/cannabinoid tolerance, this has been extensively discussed here, but it is not at all a potentiator of any opioids, including kratom. Furthermore, as has been mentioned, if taken close to your kratom dose, it would undermine it. I take mine about once a week, closer to midday, and by the next morning, I am almost completely reset, meaning that I get full benefit from my kratom whereas before, it was starting to wane. Also, when I took PEA daily, I stopped feeling kratom altogether because the PEA somehow blocked it. Within 24 hours upon discontinuation of daily PEA intake, my kratom started to work again, but much better than before the PEA blockade which daily intake creates. I suggest once or twice per week dosing pattern as it is more than sufficient to alleviate the ever forming opioid tolerance which kratom use creates. Cat's Claw extract is another MUST in our battle against the evil tolerance, every other day, after your last daily kratom dose. Caveat, Cat's Claw has some stimulating effects which must be mediated considering that for our purpose, it must be taken closer to the evening. Kratom on, children of pain...

I've read a few scientific articles past week and concluded that PEA CAN be taken concurrently with opioids like kratom. It does not block any effects. It reduces your tolerance and improves the effects.

[Laika]

Where do you get your Chinese cats claw?

I have the following.....

https://www.google.com/url?sa=t&source= ... ObplTLekG8

I use this and chelated Magnesium. The PEA didn't work out for me. Not saying it doesn't work, it just didn't work for me. Best of luck to everyone!

That's precisely the one that I myself had tried as an alternative to the regular Cat's Claw. For some reason, it was triggering mild headaches in me, but it could work for others. The only reason that I use the regular Cat's Claw is because I know that it works for me, and quite well might I add. The NOW brand of regular Cat's Claw EXTRACT that I get from Amazon is quite effective when compared to the non extract version of it (Starwest Botanicals), not to mention cheap.

How do I even know that it does anything? I stop getting benefits (mood lift) from kratom within about a week off of that Cat's Claw extract. I also start getting mild withdrawals about 8 hours after my last daily kratom dose if I skip my Claw for a few days. So, needless to say, it is an absolute MUST for me, but I still take some days off of it. Most of the time, I just take the turmeric extract or PEA or even the DLPA to alternate. Perhaps, I need to revisit the Chinese version which was referenced here earlier, but personally, I see no reason to change what's clearly working for me.

Also, a yet another added benefit, Cat's Claw is an immune system stimulant. In fact, most take it specifically for that purpose, and now days, it especially matters. I will also attest to its immune stimulating capacity, albeit I can not be completely certain on that one, but I take it at least every other day and I am yet to get a cold in the past couple of years. Also, I have heard that kratom itself is an immune system booster.

can cats claw be taken before bed?

[Burninator]

Theanine - what you said about dark chocolate blockading the mood lift effects might actually apply to me too. I’ve been a chocolate junkie for the past month or so and have also noticed Kratom stopped doing much for me moodwise. I’m going to (attempt to) break free for a few days and report back. As much as I don’t want to give it up, I would be really happy if my problems were as simple as that.

A few questions: do you take turmeric and dlpa (agmatine too I guess) every day? When specifically do you take them, and how many mgs of those as well as cats claw and PEA do you take? Also, do you supplement with BSO at all?

[YngwieShreds]

Been reading this thread off and on for a few days... So what's the consensus overall in terms of which PEA is worth getting? I know people mentioned a bunch of places/brands to get it, but curious which is likely the best? I'm going to get some and just don't want to order a bunk type of it...

[acejestyr15]

Theanine - what you said about dark chocolate blockading the mood lift effects might actually apply to me too. I’ve been a chocolate junkie for the past month or so and have also noticed Kratom stopped doing much for me moodwise. I’m going to (attempt to) break free for a few days and report back. As much as I don’t want to give it up, I would be really happy if my problems were as simple as that.

A few questions: do you take turmeric and dlpa (agmatine too I guess) every day? When specifically do you take them, and how many mgs of those as well as cats claw and PEA do you take? Also, do you supplement with BSO at all?

Interesting for sure!! I have been hammering down those new Mint Dark Choco kit Kats like it's part of my job and I've noticed my doses don't help with mood lift much if at all recently too.... Guess I'll have to stop eating those and see what happens! Thanks Theanine!!!

[BallzDeep9]

Theanine - what you said about dark chocolate blockading the mood lift effects might actually apply to me too. I’ve been a chocolate junkie for the past month or so and have also noticed Kratom stopped doing much for me moodwise.

Chocolate junkie here. yeah I've never noticed any decrease in mood-lift associated with my chocolate fetish? I do usually consume my chocolate at night before bed, so the opposite of kratom (consume morning and mid-day), but... yesterday had a heapin' helpin' of Double Chocolate ice cream w/ piece of 60% dark chocolate. Today my kratom feels great, as usual!! So... what is the reasoning behind this?

Advise anyone to Search Reddit for anything posted by 1 person on MM or any Forum.. Let the Knowledge Base of 50K kratomites on Reddit be your guide. Mostly recipes for chocolate kratom, and people who love doing chocolate WITH kratom! LINK

An opioid is any substance that binds to the opioid receptors of one’s brain in a substantial way. Furthermore, just because a substance binds to one’s opioid receptors does not mean that the substance is dangerous. For example, dark chocolate contains a compound known as epicatechin which binds to the delta-opioid receptors and various dairy products contain beta-casomorphins which are groups of peptides with opioid properties.

[Laika]

I considered making a new topic but figured I'd just post my question here:

Does anyone have a tolerance reduction regimen?

I've been searching all throughtout this forum, this topic, and the internet in general for guidance on when to take DLPA especially. Some people say to take it with your dose. Some people say not to. Some people say take it before bed. Some people say it affects your quality of sleep. All anecdotal.

Can someone who has really looked into this and researched it post their regimen?

This will give new people a starting point for cat's claw, magnesium, DLPA, and PEA and then they can adjust according to what work for them personally.

[Laika]

I considered making a new topic but figured I'd just post my question here:

Does anyone have a tolerance reduction regimen?

I've been searching all throughtout this forum, this topic, and the internet in general for guidance on when to take DLPA especially. Some people say to take it with your dose. Some people say not to. Some people say take it before bed. Some people say it affects your quality of sleep. All anecdotal.

Can someone who has really looked into this and researched it post their regimen?

This will give new people a starting point for cat's claw, magnesium, DLPA, and PEA and then they can adjust according to what work for them personally.

Somehow found this post pretty much immediately after posting:
viewtopic.php?p=27995#p27995

Answers most of my questions. I'll leave it here instead of deleting my original post in case others are looking for something like it. It's a pretty good resource.

[Burninator]

I considered making a new topic but figured I'd just post my question here:

Does anyone have a tolerance reduction regimen?

I've been searching all throughtout this forum, this topic, and the internet in general for guidance on when to take DLPA especially. Some people say to take it with your dose. Some people say not to. Some people say take it before bed. Some people say it affects your quality of sleep. All anecdotal.

Can someone who has really looked into this and researched it post their regimen?

This will give new people a starting point for cat's claw, magnesium, DLPA, and PEA and then they can adjust according to what work for them personally.

Somehow found this post pretty much immediately after posting:
viewtopic.php?p=27995#p27995

Answers most of my questions. I'll leave it here instead of deleting my original post in case others are looking for something like it. It's a pretty good resource.

Thanks. This is exactly what I was wondering.

[Laika]

Should Cat's Claw be taken every night?

[WickedMadScientist]

A Canada-based company, FSD Pharma, is engaged in the cultivation of cannabis and has started a clinical trial with PEA on COVID infected subjects last December. Ticker symbol $HUGE for those of you that dabble in stocks

https://clinicaltrials.gov/ct2/show/NCT ... w=2&rank=8

PEA protects cells, stabilizes MCAS and is anti-inflammatory. It demonstrates a variety of properties in animal model studies that suggest it might be helpful in fibromyalgia and/or chronic fatigue syndrome (ME/CFS). PEA inhibits the release of both preformed and newly synthesised mast cell mediators, such as histamine and TNF-alpha. PEA, as well as its analogue adelmidrol (di-amide derivative of azelaic acid), can both down-regulate mast cells.

One of the most profound benefits of PEA is its effect on glial cells. When glial cells become too active, they can cause brain inflammation. PEA modulates and reduces glial cell activity. This is the main reason why PEA has been found to be an effective treatment for autism. Many people notice that supplementing with PEA can reduce brain fog and improve cognitive function.

[WickedMadScientist]

Last post on this topic was September 8th. Anyone have any updates on the effectiveness of PEA after some time?

I've been taking the PEA (whole pill, AM or PM, doesn't matter) for 3-5 days in a row every month or two to keep things in check. It seems like it pretty much resets my tolerance in that timeframe consistently. Maybe it's placebo, but hell if it works, it works.

I still use it as part of my tolerance mitigating regimen, in cycles. It works quite well.

I have a new one for you guys, Shilajit. Google it. I never thought it a tolerance reducer, but after skipping my doses for 10 days, I found my tolerance jumping until I added it back into my regimen. Inexplicable!

Tried several different shilajits. It’s such an amazing concoction of earth. You ALWAYS want to make sure you are paying top dollar for good, pure stuff. If you consume poor quality you are playing with fire. Also for those that do not know, don’t take your Kratom with, or close to you taking shilajit.

Hands down best shilajit, you literally feel it working instantly and is very potent. It’s like gods multivitamin. Love to add a pea size to a fresh brewed green tea with coconut oil. The green tea synergizes with shilajit and brings about the effects really well, and the fat aids to the absorption.

https://www.amazon.com/Authentic-Shilaj ... B0098TN3NA

Info on the science behind Shilajit:
https://selfhacked.com/blog/shilajit/

[starshine]

Tried several different shilajits. It’s such an amazing concoction of earth. You ALWAYS want to make sure you are paying top dollar for good, pure stuff. If you consume poor quality you are playing with fire. Also for those that do not know, don’t take your Kratom with, or close to you taking shilajit.

Hands down best shilajit, you literally feel it working instantly and is very potent. It’s like gods multivitamin. Love to add a pea size to a fresh brewed green tea with coconut oil. The green tea synergizes with shilajit and brings about the effects really well, and the fat aids to the absorption.

https://www.amazon.com/Authentic-Shilaj ... B0098TN3NA

Info on the science behind Shilajit:
https://selfhacked.com/blog/shilajit/

I've been wanting to try shilajit. I was looking at this one. have you tried this one? or how do you think it compares to the one you recommended?

https://www.amazon.com/dp/B07T92GHV4/re ... UTF8&psc=1

[Bubba5150]

I purchased the recommended brand of PEA and am currently on day 3. So far I have noticed two things. 1. I wake up in the morning feeling less groggy. 2. I take the same amount of kratom and still feel diminished effects of kratom, basically the indicator for me that I need a break, but the wow factor has not returned for me at least. Only day three so will keep going and see if that changes. I have never had an issue tapering my use and takin a couple of weeks off to reset. If I can avoid that with PEA’s great, will post again next week after further use.

[MycatTimmy]

I purchased the recommended brand of PEA and am currently on day 3. So far I have noticed two things. 1. I wake up in the morning feeling less groggy. 2. I take the same amount of kratom and still feel diminished effects of kratom, basically the indicator for me that I need a break, but the wow factor has not returned for me at least. Only day three so will keep going and see if that changes. I have never had an issue tapering my use and takin a couple of weeks off to reset. If I can avoid that with PEA’s great, will post again next week after further use.

Please keep us posted as I’ll be following. Good luck

[Kryptongame]

Just got mine in the mail. From ND. Going to try right now

[Bubba5150]

I purchased the recommended brand of PEA and am currently on day 3. So far I have noticed two things. 1. I wake up in the morning feeling less groggy. 2. I take the same amount of kratom and still feel diminished effects of kratom, basically the indicator for me that I need a break, but the wow factor has not returned for me at least. Only day three so will keep going and see if that changes. I have never had an issue tapering my use and takin a couple of weeks off to reset. If I can avoid that with PEA’s great, will post again next week after further use.

Please keep us posted as I’ll be following. Good luck

One week from my last post, so 10 days total. In short, I will not be purchasing any more and will likely quit taking the current PEA I purchased. No break in tolerance whatsoever, I need to take just as much, if not more, to get where I want to be. If it is working for others I am insanely envious, trust me, I really wanted this to work. I suppose a good ol' taper will just have to suffice for me I think it is a good time for me to do one anyway. The less grogginess could be attributed to a few factors and is not enough by itself for me to justify the purchase of more. Like everybody, I love me a good shortcut, but this just does not seem to be any help for me. I hope others get some help from it.

[MycatTimmy]

I purchased the recommended brand of PEA and am currently on day 3. So far I have noticed two things. 1. I wake up in the morning feeling less groggy. 2. I take the same amount of kratom and still feel diminished effects of kratom, basically the indicator for me that I need a break, but the wow factor has not returned for me at least. Only day three so will keep going and see if that changes. I have never had an issue tapering my use and takin a couple of weeks off to reset. If I can avoid that with PEA’s great, will post again next week after further use.

Please keep us posted as I’ll be following. Good luck

One week from my last post, so 10 days total. In short, I will not be purchasing any more and will likely quit taking the current PEA I purchased. No break in tolerance whatsoever, I need to take just as much, if not more, to get where I want to be. If it is working for others I am insanely envious, trust me, I really wanted this to work. I suppose a good ol' taper will just have to suffice for me I think it is a good time for me to do one anyway. The less grogginess could be attributed to a few factors and is not enough by itself for me to justify the purchase of more. Like everybody, I love me a good shortcut, but this just does not seem to be any help for me. I hope others get some help from it.

Thanks for the follow up Bubba. I’m so sorry it didn’t work for you and disappointed for all of us. The only positive effect I’ve seen posted is that some people notice a slight reduction in pain levels. After everything I had read on this post I decided not to invest the money. So thanks to everyone who tried it and posted their results. Y’all saved the rest of us a little money.
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