METHYLENE BLUE: katom contraindications?

[brassy]

Has anybody here ever ever taken Methylene Blue and kratom on the same day?

I know that MB can act as a MAOI inhibitor and have read that combined with high doses of kratom, one might be at risk for seratonin syndrome but found no scientific/medical references for this statement (also, what is considered a high kratom dose?)

There are a bazillion potential contraindications with any substance that can function as a MAOI inhibitor, no doubt, but I have been prescribed actual MAOI inhibitors as antidepressant. I found them extremely effective at the time and felt that tradeoff was well worth being ever-mindful of dietary restrictions and contraindications with prescriptions, OTC Meds, aminos, herbs and recreational drugs. Also, I do not have high blood pressure or any other condition for which I am dependent on medication for maintenancem which makes it a big easier.

I am just wondering whether I need some kind of washout period with kratom. I'd rather use them concurrently. Never had a single problem with kratom in six years. Very helpful for my ADHD, low mood and chronic pain from an unrelated gut issue.
What I am hoping is that I might get the adderall like increased energy and focus that some users report from methylene blue.

Given increasing anti-kratom legislation and the reefer-madeless like hysteria I have witnessed even in unlikely places such as Reddit, I feel it is especially useful at this time to experiment with potential alternatives.
I'll try anything that's reasonably safe at this point so I'm not going to rule out MB just because RFK Jr. is a twit.

• If any of you do take methylene blue, which form factor do you think is preferable, powders or liquids?
  
  Do you have any noteworthy vendors to recommend?
  
  If you don't mind, please share your dosing schedule of MB and/or kratom and whether you take them concurrently.

Thank you for your insights!

PS: I prefer not to buy supplements off Amazon, not only because I have received both counterfeit and expired products in the past but because their comingled inventory system means buyers are subject to the luck of the draw when their orders are fulfilled (no matter how carefully you select your Amazon vendor, your product will be pulled at random from a bin of multiple vendors products with like ASIN numbers).

[Kelleytoons]

Actually, you and I disagree completely on RFJ - he's the reason I started taking this.

But I haven't noticed anything between the two that makes any difference. I take a pill, usually at lunch, and my kratom usage (when I take it - right now I'm using 7oh almost exclusively) is in the morning and at night.

However - I will say I'm considering stop taking MB because I don't know if it really does anything. I've been on it for at least two or three months now and other than my weird urine I don't see any changes in ANYTHING. So I might just save the money.

[brassy]

Thanks for responding -- I don't feel particularly anti- RFK Jr -- just a bit put off regarding his take on autism and ADHD, as someone who has those disorders.
It's not even about the supposed autism/vaccine link -- it's the idea of any government administrastion shipping us off to "wellness" camps.
As it happens, I agree with his takes on both fluoride and seed oil. Abandoned virtually all packaged foods about five years ago, due to the latter. It's a PITA making everything from scratch but I do feel better.
Anyhow, I I just took my first dose of MB (5 drops, 2.5 mg) -- I put the drops in a capsule so my mouth wouldn't turn blue. Nothing so far, but that's a low dose and it's early days.
How many milligrams of MB do you take a day, if you don't mind my asking? Two or three months is a reasonably long trial.
I downloaded the Sloan book, so I am starting off at 2.5 mg AM & PM (I weigh around 120 lbs), which is about what Sloan recommended.
I'm a little disappointed in the book which I expected might be a bit more professional, with better references.
I was actually going to try the vendor he recommended in it, but when I followed his link, it went to a website called https://endalldisease.com which kind of blew whatever credibility I was expecting from the author.
Cheers!

[Kelleytoons]

The capsule is 12mg - but, again, I think I'm going to stop taking it because I didn't notice any difference in anything.

(Now - I don't really know what it's supposed to do, either - sometimes it's best not to read too much or you get placebo effects. But I wouldn't mind knowing, now, what it's supposed to accomplish).

[brassy]

Hi again, Kelley --
I only feel one effect so far (apart from initial dizziness) -- I'm waking up fully alert. This isn't a benefit in my case because I have to rouse at least 4X each night to care for my incontinent, disabled dog and prefer to get right back to sleep, but it's pronounced so I am hoping it's a sign of stamina improvements to come? So far it isn't, I'm petering out every afternoon as usual. As far as what it is supposed to do, that depends on whether you're talking anecdotally or basing it on peer reviewed clinical trials. I've read a ton of both and it's pretty muddled ... it may have dose-dependent neuroprotective effects and it definitely crosses the blood-brain barrier, unlike a lot of other supplements which cannot do so directly. It also has some antiviral activity.
The data isn't impressive, by any means, but that could be said for many routinely prescribed drugs including antidepressants and cancer meds. The way I figure it, there isn't much data supporting kratom's beneficial affects, but we know it works.
MB is probably BS, but I got it super cheap and it doesn't have any taste, so I'm going to keep trying until I am taking at least 25mg a day before I write it off as useless.
I used to drink a ton of strong Yerba Mate tea every day and that stuff works great for stamina and focus, but it tastes like pond scum to me.
btw -- if you need to reorder, the liquid is radically cheaper than pre-filled capsules and you can just drip your drops into a gelatin capsule so your tongue doesn't turn blue. Five drops barely coats the bottom so at .5mg per drop, you could probably fit a 50mg dose in one capsule.
Amazon seems to always have a subscribe & save coupon for the liquid brands. Mine was called PureGood, cost was $23 for two two-ounce dropper bottles after 40% off (I just cancel my S&S subscriptions right after checkout).
All best, Amy

[Pixiedust]

I haven't tried it but I've seen some reviews, enough to make me curious about it. I've done a little bit of research on it but haven't dug super deep into it. It does peak my interest though. I'm also interested to see if it has actually helped people or if the reviews I've seen are paid reviews to get people to buy it.

[brassy]

Well, I lasted 13 days -- got up to 13 drops, twice a day, so 13mg total and I felt absolutely zero positive effects. In fact, I think it raised my blood pressure but my blood pressure cuff was broken so I can't be sure. I know I said I was going to keep it up until I got to 25mg since some people say you need that much for perceptible changes, but nope, definitely do not like it -- giving my bottles to a neighbor to try.
If there was any kind of clinical data providing support for the anecdotal claims being made, I'd persist, but there isn't.

[IndelibleDotInk]

I'm trying the pill version I found out about from Candace Owens (journalist and story hound), it's from Melaluca, The Wellness Company, they're like Amway/QuickStar, but they put out cost saving (not sure the particulars of this one supplement) and quality products.

If it increases my blood pressure, that wouldn't be optimal for me.... gotta look into this.

[IndelibleDotInk]

Gotta get in contact with my PCP to ask if using this will require adjustment to my blood pressure meds (I have high bp), and am waiting for my shrink to give the go, since SSRI syndrome can occur and i take Cymbalta (SSNRI which also affects serotonin). Hope I am good to go, surprised by how blue my pee turned (I tried one dose before calling the docs).

[BallzDeep9]

Saw this weeks ago... Never Heard of it... I'm NOT on "Tik Tok"... So it's a Synthetic Dye.

Full Stop. You'd have to be, at least very gullible or... Really into "Social Media Fads" whatever.. it's The Cinnamon Challenge. AGAIN.

As far as RFK - NO, he should NOT be running H.H.S... come on. Sure maybe he's had a few interesting ideas ? But his RATIO of "good ideas" to absolute nonsense... Way too Low for me. Spent 10 years addicted to dope ?? Good for him... Maybe he can help someone... For Sure he needs to try 7OH!!

[ivanquamay]

To everyone who's taking it, just curious, what are you or were you looking for it to accomplish? Does RFK give a reason why he takes it?


edit : I looked all of the particulars of the stuff itself and all I see is mays and mights. Even if it's the best shit on earth, is there any chance to take it without Methlyene Blue-in' your entrails? There's gotta be a better way.


Dollars to donuts RFK has stock.in it and that pic was an ad.

That's how every single one of us found out. That weird picture.

Jokes on y'all that was actually MDMA.



You didn't hear it from me though.

Truth is I don't trust a single one of these ********ers (I think that's the right # of asterisks...haha)

I'm leaving Germs up another day
Because that rhymes with RFK.


Love you guys, but this life shit.....

[biggreenmat]

I've taken both concurrently. Up to 30mg of methylene blue and up to 8 g of kratom. Zero issues taking both at once or concurrently over 3 or 4 days. Tried Methylene Blue for mitochondrial and energy support. It could be placebo, but I feel a bit more resilient. I tend to only take it for 3 or 4 days then take breaks.