Boost/Potentiate kratom's: Duration/Potency and BA

[PsilocybeFanaticis]

I seen a post talking about a nootropic drink so I thought why not share what I use. I have a very large tolerance to opioids and mitragynine and take more than 10g to get effects from powdered leaf .

I use BioPerine tablets which contain 95% pure Piperine which is in black Pepper. This is so much more effective than black pepper by itself. So if you tried black pepper or Grapefruit juice with no boost in effects don't let it discourage you from trying BioPerine.

How it works:

Piperine inhibits the CYP3A4 enzymes which allows more of the opioids in kratom like mitragynine to get into the blood stream and exit through the CNS. Normally you only get around 30-40% BA from oral ROA of kratom leaf and taking CYP3A4 inhibitors can increase it by 15-25%, I'm not positive what the actual number of increase is of the BA since multiple studies have differing stats.

So taking Piperine with your kratom increases the Bioavailability (BA) of kratom orally taken.

This does multiple things:
it lowers the required dose needed for full effects!

it increases the potency of your normal dose taken by mouth in powder form.

it also increases the Duration that the kratom effects you, for example: 3-4 hours becomes 5-7 hours from a single dose only taking one 10mg tablet of BioPerine 1-2 hours prior to consumption.

I normally take 10g of my best kratom and only need 6g or 7g when taking one 10mg BioPerine tablet with it and it feels better than it would to take 10g of the kratom by itself.

Check out my guide to kratom potentiators:
https://www.reddit.com/r/Kratomm/commen ... it-android

Warning: Check out this potentiator and I promise it won't disappoint. Just don't take it longer than a month and only take them twice a day at most at least 6 hours apart since frequently blocking enzymes which aid in breaking down foods could cause a buildup of unhealthy toxins! Just make sure to take decent breaks when using potentiators

Warning: Check drug interactions between your supplements, herbs, pharmecuticals, prescriptions and kratom/BioPerine. Some things use the CYP3A4 enzyme and its better to be safe than sorry. If you are taking Rx medications or any Botanical I encourage all of you to research drug interactions between your meds and BioPerine as well as kratom, it can be very dangerous and even fatal if the wrong combo is used. Some have blood pressure problems and the medication they take could be blocked by CYP3A4 inhibitors this includes: ruby/White Grapefruit juice, black pepper, tumeric and Piperine containing products!!! i strongly advise all to stay away from using multiple potententiators at the same time. It can be very harmful and deadly.

Please go to these links before ingesting BioPerine tablets:
Drug interactions:

https://www.webmd.com/drugs/2/drug-1505 ... medication

Possible dangers of BioPerine:

https://www.leaf.tv/articles/the-dangers-of-bioperine/

Conclusion:

Just wanted to help out the fam! Or anyone struggling with tolerance or just needing that extra push from their leaf or just need an extra bump to get the most out if their leaf to get out of pain or depression.

Stay safe, test before you ingest and make sure to do your research on possible drug and botanical interactions between every substance and combo you are taking.