Palmitoylethanolamide - a novel OPIOID tolerance reducer

[Nic]

I have been using comfortmax for the last week. I took half of a pill the first two nights and I have been rotating the whole 600 AM and PM for the last five nights. The only other thing I take with kratom is 1 gram of moringa with the first dose each morning. The comfort max really helps me to sleep better through the nights and when I wake up I am way less irritable. I was wondering if it was dulling the effects of kratom a little, but I also lowered my doses by a gram this week. I did buy some cats claw but I have not tried it yet. This P will be very helpful for tapering in my opinion. The difference it has made in my sleep is great.

[Payshince]

I have Not gotten any PEA
Yet.

I did however get some DLPA from Amazon
and L-Phenylalanine from ND.

I’m kinda scared to try them.

Not like really scared or anything haha but worried I might feel like shit!

I havent been feeling 100% or even 90% lately.
I take a decent amount of herbal supplements daily and every other day and some days I get headaches some days I dont.
Just sick and tired of the fucking side effects!

[Theanine]

I have Not gotten any PEA
Yet.

I did however get some DLPA from Amazon
and L-Phenylalanine from ND.

I’m kinda scared to try them.

Not like really scared or anything haha but worried I might feel like shit!

I havent been feeling 100% or even 90% lately.
I take a decent amount of herbal supplements daily and every other day and some days I get headaches some days I dont.
Just sick and tired of the fucking side effects!

It is unlikely that you would even feel the DLPA, it doesn't really produce any psychoactive effects. Take it APART from your Kratom if you'd like. Also, you do not need the L-Phenylalanine separately, DLPA has BOTH -- L-Phenylalanine and D-Phenylalanine. Report back!

[Choppy_Shores]

I got some of this stuff and It really doesn't seem to be doing anything for my tolerance. I took it two days in a row before bed, then tried to cycle it once every three days and then every other day and it seems like my tolerance has just steadily increased as it usually would with no tolerance reducers. Am I missing something? Does anyone have anything new to report? Is it still working for those of you who noticed a tolerance improvement? Should I be taking it on an empty stomach or with something fatty maybe? I suppose I'm just going to have to taper down and go back to using agmatine/dlpa for the time being.

[Theanine]

I got some of this stuff and It really doesn't seem to be doing anything for my tolerance. I took it two days in a row before bed, then tried to cycle it once every three days and then every other day and it seems like my tolerance has just steadily increased as it usually would with no tolerance reducers. Am I missing something? Does anyone have anything new to report? Is it still working for those of you who noticed a tolerance improvement? Should I be taking it on an empty stomach or with something fatty maybe? I suppose I'm just going to have to taper down and go back to using agmatine/dlpa for the time being.

Why don't you just take all of your tolerance reducers? There is no danger in that, I do. Why cut out the Agmatine or the DLPA? They do not interfere with each other, stacking them is perfectly acceptable. I also take all of the above with no ill effect. I do cycle my Palmitoylethanolamide though. Personally, I have only had my tolerance be this low within the first few months of my kratom journey. My morning dose is only 3.5 grams now, even less works. At some point, I was at a 10 gram per dose level, only about 6 months into kratom. Now, a year later, I only need a third of that dose. Since you take kratom daily, you must beat down that tolerance daily also. You must still monitor your kratom dosages, take daily tapers, etc. Tolerance reducers only assist in tolerance reduction. My own regimen has been more effective with the addition of this substance, it does work for me, but it is only one of several tools in my belt. I would not dare dropping my entire TR regimen for a single substance. It is far more useful to simply add it to your existing regimen. No one stops taking DLPA if they start taking Agmatine, or vice versa. In addition to all of that, I also take Cat's Claw and Hirsuta now, also various forms of Magnesium and a Turmeric extract, yes ALL of them! That's what it takes.

[Haid3r]

Wellll... It was an interesting nine days of testing, but I've stopped taking ComfortMax. The beneficial effects on my daily burn dissipated after two days, sleep benefit became negligible, and I experienced a ridiculous increase in minor kratom side effects like watery eyes and nose. My whole head was running like a faucet as soon as I woke up in the morning. The returns just weren't worth it.

I must emphasize, I only take 2.5–3g 1x/day, so I didn't use PEA to reduce my dose. If you're currently taking a larger dose and you're looking for a way to scale back or taper, ComfortMax may be an ideal solution for you. Personally, I didn't find it improved my small daily dose.

Comfortmax was an interesting experiment, thank you, Theanine for staying engaged in this thread.

[Choppy_Shores]

Why don't you just take all of your tolerance reducers? There is no danger in that, I do. Why cut out the Agmatine or the DLPA? They do not interfere with each other, stacking them is perfectly acceptable. I also take all of the above with no ill effect. I do cycle my Palmitoylethanolamide though. Personally, I have only had my tolerance be this low within the first few months of my kratom journey. My morning dose is only 3.5 grams now, even less works. At some point, I was at a 10 gram per dose level, only about 6 months into kratom. Now, a year later, I only need a third of that dose. Since you take kratom daily, you must beat down that tolerance daily also. You must still monitor your kratom dosages, take daily tapers, etc. Tolerance reducers only assist in tolerance reduction. My own regimen has been more effective with the addition of this substance, it does work for me, but it is only one of several tools in my belt. I would not dare dropping my entire TR regimen for a single substance. It is far more useful to simply add it to your existing regimen. No one stops taking DLPA if they start taking Agmatine, or vice versa. In addition to all of that, I also take Cat's Claw and Hirsuta now, also various forms of Magnesium and a Turmeric extract, yes ALL of them! That's what it takes.[/quote]

I'll go ahead and give taking all that stuff a shot. I was just trying to assess the benefits of the pea on its own. Thank you for posting your entire regimen here, its very helpful for me to know it is probably gonna take all that stuff. I'll go ahead and order some cats claw and hirsuta, those are the only things I don't currently have right now.

[Lambeezy]

I’ve been researching and playing around with these tolerance reducers here lately. The PEA might be helping, I take it every 3 days but it doesn’t reduce tolerance it just stops it from rising. Cats claw does work but it is not to be taken every day. You can actually build a tolerance to NMDA agonists and it will start blocking some of the effects of kratom. It should only be taken every couple of days also.

[Theanine]

I’ve been researching and playing around with these tolerance reducers here lately. The PEA might be helping, I take it every 3 days but it doesn’t reduce tolerance it just stops it from rising. Cats claw does work but it is not to be taken every day. You can actually build a tolerance to NMDA agonists and it will start blocking some of the effects of kratom. It should only be taken every couple of days also.

A good point about the NMDA antagonists resistance. Such does indeed occur with the repeated administration of the NMDA antagonists. Of course, opioid tolerance reduction is a LOT more than simple NMDA antagonism! Still, it is well advised to cycle your tolerance reduction stacks.

[guitartodd77]

I’ve been researching and playing around with these tolerance reducers here lately. The PEA might be helping, I take it every 3 days but it doesn’t reduce tolerance it just stops it from rising.

I'm doing something similar to what Lambezzy mentioned. I now take 400mg of PEA 2x a week; Cats Claw 2x week and DLPA 3x week. They are all staggered so I'm taking something every night of the week. I had also taken a 4 day (ok... 3.5 days ) tolerance break almost a week ago and so far I'm getting consistently good burns on 4gs with various batches. In the past, I would get great burns for 2 days after a t-break then notice that magic beginning to fade on day 3. Not the case so far. I'm sticking to this schedule until I begin to notice a consistent tolerance increase and then I'll reassess. I'll post again when/if this happens.

Oh... a completely separate side note, I've started taking shilajit every day as well but not for tolerance. It's for ageing related issues. I'm middle aged and can use all the help I can get. I doubt it helps with anything related to Kratom but it does seem to add some slight increase in sustained positive energy. Probably placebo effect but I'll take it.

Thank you Theanine and everyone else for recommendations and feedback. I'm looking forward to maintaining positive results moving forward.

[Theanine]

I’ve been researching and playing around with these tolerance reducers here lately. The PEA might be helping, I take it every 3 days but it doesn’t reduce tolerance it just stops it from rising.

I'm doing something similar to what Lambezzy mentioned. I now take 400mg of PEA 2x a week; Cats Claw 2x week and DLPA 3x week. They are all staggered so I'm taking something every night of the week. I had also taken a 4 day (ok... 3.5 days ) tolerance break almost a week ago and so far I'm getting consistently good burns on 4gs with various batches. In the past, I would get great burns for 2 days after a t-break then notice that magic beginning to fade on day 3. Not the case so far. I'm sticking to this schedule until I begin to notice a consistent tolerance increase and then I'll reassess. I'll post again when/if this happens.

Oh... a completely separate side note, I've started taking shilajit every day as well but not for tolerance. It's for ageing related issues. I'm middle aged and can use all the help I can get. I doubt it helps with anything related to Kratom but it does seem to add some slight increase in sustained positive energy. Probably placebo effect but I'll take it.

Thank you Theanine and everyone else for recommendations and feedback. I'm looking forward to maintaining positive results moving forward.

No worries, glad to do it! Staggering and rotating your tolerance reducer stack is well advised. I have recently added Smiley's Premium Mitragyna Hirsuta to my regimen. Next up is stem 'n vein. The more the better, but you're correct, it is best to use a single TR in any given category. For example, either Cat's Claw or Stem 'n Vein or Hirsuta, not all at once, but rather cycled and used on different days. DLPA can be taken daily, but I still cycle even that one, Agmatine as well.

I think Shilajit adds vitality to my daily experience. It is chock full of minerals, I take it with my Iodine. Of course, I also use the Carbon 60 and the Mega Hydrate silica, they compliment the Shilajit, but it's a different topic entirely....

[dyslexyk]

i didnt read this entire thread, but i found PEA in bulk from Quality Chemicals Co. they third party lab test in the US, so you can trust it. its much cheaper than bottles of caps or tablets. 50g is less than $40

[Theanine]

i didnt read this entire thread, but i found PEA in bulk from Quality Chemicals Co. they third party lab test in the US, so you can trust it. its much cheaper than bottles of caps or tablets. 50g is less than $40

https://www.amazon.com/Life-Extension-C ... B0777MDGPC

Life Extension ComfortMAX, 30 AM Vegetarian Tablets, 30 PM Vegetarian Tablets by Life Extension

60 tablets x 600 mg = 36 grams for $21 including shipping, that comes to about $30 for 50 grams.

Also, it is far more convenient in a tablet, but some might actually prefer powder.

Thank you for sharing!

[dyslexyk]

https://www.amazon.com/Life-Extension-C ... B0777MDGPC

Life Extension ComfortMAX, 30 AM Vegetarian Tablets, 30 PM Vegetarian Tablets by Life Extension

60 tablets x 600 mg = 36 grams for $21 including shipping, that comes to about $30 for 50 grams.

Also, it is far more convenient in a tablet, but some might actually prefer powder.

Thank you for sharing!

have you checked the label for buffers and fillers? the one is a 99% pure, no filler or additive. anything that is pressed or capsuled will generally have other, less beneficial ingredients to bulk the product out.
to each their own, but if, say, you have liver problems or other organ issues. or maybe a 20g/day kratom habit you may want to be conscious of what it is exactly that is going into your body. even extra amount of silica and cellulose arent good for you. especially if like many kratom users you have added or stacked multiple supplements.
i always suggest finding the most pure source ingredients when heavily supplementing


heres a picture from amazon of the back label. all kinds of nasty shit in there. be safe bro. its easy to delude onesself into thinking that we are taking "the high road to health and wellness" but that isnt the case all the time. speaking from experience.

https://images-na.ssl-images-amazon.com ... L1500_.jpg

and heres a link to the product i was mentioning:

USA LAB Tested Bulk Ultra-micronized Palmitoylethanolamide Powder 99% Pure (50 Grams) https://www.amazon.com/dp/B07NJ7GLXD/re ... ADbHQ65Q7E

you know what they say though.... you can lead a horse to water......

[Theanine]

https://www.amazon.com/Life-Extension-C ... B0777MDGPC

Life Extension ComfortMAX, 30 AM Vegetarian Tablets, 30 PM Vegetarian Tablets by Life Extension

60 tablets x 600 mg = 36 grams for $21 including shipping, that comes to about $30 for 50 grams.

Also, it is far more convenient in a tablet, but some might actually prefer powder.

Thank you for sharing!

have you checked the label for buffers and fillers? the one is a 100% pure, no filler or additive. anything that is pressed or capsuled will generally have other, less beneficial ingredients to bulk the product out.
to each their own, but if, say, you have liver problems or other organ issues. or maybe a 20g/day kratom habit you may want to be conscious of what it is exactly that is going into your body. even extra amount of silica and cellulose arent good for you. especially if like many kratom users you have added or stacked multiple supplements.
i always suggest finding the most pure source ingredients when heavily supplementing

Very true. For some, bulk powder would indeed be preferable. Thanks for the heads up!

[CatfatherB]

Has anyone tried SAM-e for tolerance reduction? There's an study posted on a r/kratom thread I was reading a while back that has said it reverses tolerance to morphine in rats, maybe using this on alternate days as PEA or nmda antagonists.

I would link it if I weren't limited in my technical skills

[BurntEnds]

Has anyone tried SAM-e for tolerance reduction? There's an study posted on a r/kratom thread I was reading a while back that has said it reverses tolerance to morphine in rats, maybe using this on alternate days as PEA or nmda antagonists.

I would link it if I weren't limited in my technical skills

Huh!? I've been taking SAMe for most of the past couple years as it's so helpful for depression and joint mobility/pain...I had no idea!

I can't find the Reddit post referring to the specific article but I did find this short study finding posted online through NCBI:

https://www.ncbi.nlm.nih.gov/m/pubmed/28237804/

Not sure if it's the same study you reference or not. Really interesting stuff

FYI in order to link the article here I just copied the web address at the top of the article's page and then pasted it here in my response.

[Theanine]

Has anyone tried SAM-e for tolerance reduction? There's an study posted on a r/kratom thread I was reading a while back that has said it reverses tolerance to morphine in rats, maybe using this on alternate days as PEA or nmda antagonists.

I would link it if I weren't limited in my technical skills

Very interesting! I have tried SAM-e before as a general supplement, but it triggered some serious anxiety in me. Since SAM-e is a potent methyl donor, that reaction was likely caused by a hereditary defect which causes one to be sensitive to methyl donors.

[Kindashewantsto]

I have chronic pain, which is primarily what I take kratom for.

I've been using it for a few years now, so although it still helps a ton, it isn't as strong as it once was, of course.

I just got my order of this stuff in the mail today - taking it tonight, probably a few hours after my last kratom dose, and I will come back to update tomorrow night!

Thanks for the info - I hadn't even heard of this!

(Obviously many things work better cumulative over time, so I will be trying it out for a while then seeing where it takes me!)

[Oletimer]

I didn't read the whole thing, ,I'll just ask you, if you have chronic kidney disease can you take this? At stage 3, ,lots of things, moringa, tumeric, for example are not recommended on a daily basis, ,my kidneys can't filter nerve pain meds Gabapentin in particular, ,,so is there warnings of using this with ckd?

[Lambeezy]

I didn't read the whole thing, ,I'll just ask you, if you have chronic kidney disease can you take this? At stage 3, ,lots of things, moringa, tumeric, for example are not recommended on a daily basis, ,my kidneys can't filter nerve pain meds Gabapentin in particular, ,,so is there warnings of using this with ckd?

Not worth the risk my friend

[Oletimer]

Ok,thanks lam,, that's what I was thinking, ,,since using kratom my function has improved, ,so that's a good thing,,it's the potentiates I have to be cautious about, ,oh well, , I'll stick to t breaks,

[DrFappingston]

Last post on this topic was September 8th. Anyone have any updates on the effectiveness of PEA after some time?

I've been taking the PEA (whole pill, AM or PM, doesn't matter) for 3-5 days in a row every month or two to keep things in check. It seems like it pretty much resets my tolerance in that timeframe consistently. Maybe it's placebo, but hell if it works, it works.

[CatfatherB]

Last post on this topic was September 8th. Anyone have any updates on the effectiveness of PEA after some time?

I've been taking the PEA (whole pill, AM or PM, doesn't matter) for 3-5 days in a row every month or two to keep things in check. It seems like it pretty much resets my tolerance in that timeframe consistently. Maybe it's placebo, but hell if it works, it works.

I still use it, plus other things mentioned in this thread, I wouldn't say my tolerance resets every night but I do think this helps? Since I've started this routine there's no withdrawls during the night/morning and I'm able to go longer periods without dosing, Glad to hear from you about this Dr. Fappington, hope all is well?

[DrFappingston]

I still use it, plus other things mentioned in this thread, I wouldn't say my tolerance resets every night but I do think this helps? Since I've started this routine there's no withdrawls during the night/morning and I'm able to go longer periods without dosing, Glad to hear from you about this Dr. Fappington, hope all is well?

I've been better, but I've also been a whole hell of a lot worse, so I guess I'm doing okay. Yourself?

Perhaps there are diminishing returns utilizing PEA regularly, or interactions with the Cats Claw, DLPA or whatever it may be... Or perhaps it's just up to individual body chemistry.

[RumRunner]

Here's my question. Do we share this knowledge with Reddit?

NO WAY! It belongs to US! We keep it ALL to ourselves!

Agreed! Reddit is an information wasteland.

[Theanine]

Last post on this topic was September 8th. Anyone have any updates on the effectiveness of PEA after some time?

I've been taking the PEA (whole pill, AM or PM, doesn't matter) for 3-5 days in a row every month or two to keep things in check. It seems like it pretty much resets my tolerance in that timeframe consistently. Maybe it's placebo, but hell if it works, it works.

I still use it as part of my tolerance mitigating regimen, in cycles. It works quite well.

I have a new one for you guys, Shilajit. Google it. I never thought it a tolerance reducer, but after skipping my doses for 10 days, I found my tolerance jumping until I added it back into my regimen. Inexplicable!

[CatfatherB]

Where ya get that Shilajit from Theanine?

[Theanine]

Where ya get that Shilajit from Theanine?

Here is the one that I use: https://www.ebay.com/itm/Shilajit-Mumiy ... 3868642005

Of course, there are a lot of other sources. Amazon has it, but its overpriced there. $20 for 100 grams is about the going rate, its twice that on Amazon. 100 grams lasts about 6 months....

[guitartodd77]

Where ya get that Shilajit from Theanine?

Here is the one that I use: https://www.ebay.com/itm/Shilajit-Mumiy ... 3868642005

Of course, there are a lot of other sources. Amazon has it, but its overpriced there. $20 for 100 grams is about the going rate, its twice that on Amazon. 100 grams lasts about 6 months....

This is the same brand that I use as well and I do notice a difference after about a week of consistent use.

Many of the Kratom vendors offer Shilajit as well. I know Kats Botanicals and Odus offer it but it can get expensive.

[CatfatherB]

When do you take the shilajit, pre dose or post dose, does it have energizing properties by itself?
I've considered trying it before but didn't know it helped kratom burns?

[Theanine]

When do you take the shilajit, pre dose or post dose, does it have energizing properties by itself?
I've considered trying it before but didn't know it helped kratom burns?

I take mine in the morning, about 500mg or so. I just dilute it in hot water, then let it stand to cool it down. I have grown to actually enjoy the taste. It provides a consistent and lasting energy boost, but its NOT stimulatory! Similar to a good B complex I suppose.

Where ya get that Shilajit from Theanine?

Here is the one that I use: https://www.ebay.com/itm/Shilajit-Mumiy ... 3868642005

Of course, there are a lot of other sources. Amazon has it, but its overpriced there. $20 for 100 grams is about the going rate, its twice that on Amazon. 100 grams lasts about 6 months....

This is the same brand that I use as well and I do notice a difference after about a week of consistent use.

Many of the Kratom vendors offer Shilajit as well. I know Kats Botanicals and Odus offer it but it can get expensive.

Hmm, you're right, it is sold in a lot of kratom shops, I hadn't really looked into that. As I said, I did not intend it as a kratom enhancer, but I think it actually does potentiate! WOW, this is really a discovery for me, I didn't think much of it initially, but now I realize that I feel SO MUCH better while on it!

[3Gdd6R]

another thanks for @Theanine posting this and to all the others posting on this thread. i ordered mine today. reads really promising as another really good tool for the tool-box

[Drewbie]

Just got mine in the mail today. Took 300mg b4 bed. Looking fwd to seeing if it helps with waking up fresh.
Thanks for this info!

[plumsmooth]

So I am on about day 2 out of three PEA before bed along with an Agmatine, Cat's Claw, and Olive Leaf capsule!
One night I had a little Phenibut so I skipped that night for the Tolerance Reduction Cocktail.
I have to admit I even clicked right through to buy the Comfort Max to treat myself even after going for the bulk PEA powder first.
I own a capsule machine so I thought I would put it to work.

I have to say I am having a really nice morning (I'm not going to say burn) session on 5 grams of a mellow white that isn't my favorite.

As a matter of fact I think I am going to try 3 next time because I think this stuff is doing something.
I also want to explore some more of the combo potentiations of herbs like Bacopa and amino acids like Tyrosine.
My goal is actually to re-eliminate my morning dose and consolodate one nice afternoon session of about 6-9 grams.

Actually in the old days (I'm just over a year daily Kratom user) I found I couldn't even get off on a second session hardly. I think my brain has wired itself to Kratom. It has made me a very happy person in general so much so that I sometimes feel guilty when the mood lift (don't get it every session) kicks in.

In the morning I almost feel like I am cheating trying to get some of the wake-up stimulation from my kratom along with my Coffee. I feel if I can get through until around 3-4 PM I could potentially set myself up for the perfect afternoon EVERY day.
Otherwise I like the idea of 3 instead of 5 in the AM and topping out around 7-9 in the afternoon. Anyway some reduction would be nice to achieve but in my Heart I have to say -- espcially considering that I have basically quit alcohol altogether again.

Originally after rediscovering Kratom and becoming dependent last year I completely quit drinking beer for months and for some stupid reason allowed myself to start again. I think I may have just had a major breakthrough with a rewiring of said brain. I have started using some Kava -- which I do not think I am compatable with long term -- as an emergency substitute and I think it has replaced that Gaba craving (even considering the a vs b) effectively enough that I do not even have a good fantasy about drinking -- which usually happens after my x-country Jog around 6PM sharp. I can't tell you how deeply guilty I felt about my Liver following an afternoon dose of Kratom at 4, with drinking beers around 7-730... But I have to admit the primary motivator toward quitting drinking aside from the appetite and weight gain is... the wrecking of my Sleep! The Gaba rebound got really bad for me to where I had some nights where I could barely fall back asleep again after 3AM. That was really depressing.
One thing that amazes me about Kratom is that it can be both stimulating in the morning with a cup of coffee (as you can see I am abusing your reading right now) but I can also sleep on it -- weird...

[plumsmooth]

I forgot to mention that I have stem and Vein as well. Because one time, when I was still making tea, I got a bit queasy from it I put it in the freezer and was going to give it away. But now I think I may have just had too much at a time originally and am going to capsulize it for addition to regular dose. For Example in the AM I could try adding in half S&V giving me like a 2/2 morning dose which might calm me down a little since I tend to half an additional cup of coffee when I get excited with my AM Kratom. And maybe having some Stem and Vein in my AM dose might further contribute to keeping my afternoon tolerance at bay. Maybe replacing my morning dose with strictly S&V and some BSO might be a way to work back toward my One Dose per Day idea.

[CatfatherB]

Okay, I need help with this shilajit! I got it in the mail today, I had to pry the lid off of it, how in the hell do I measure out a quarter teaspoon when this stuff just sticks to my spoon?

[Theanine]

Okay, I need help with this shilajit! I got it in the mail today, I had to pry the lid off of it, how in the hell do I measure out a quarter teaspoon when this stuff just sticks to my spoon?

It is a bit tricky if you aren't used to it. What I have found to be the best method was to take two knives and scoop the material with one of the knives with its tip, then submerge that tip into a glass of HOT water, scrape it off clean into that water with your second knife, then simply let sit to cool down or add cool water and drink. DO NOT FREEZE or even refrigerate is, it would turn into a solid unusable rock if you do.

Take it once per day, around 500 mg, in the morning preferably. The scent of it can be off-putting, but after a while one acquires a taste for it. This stuff is LOADED with various minerals, more so than perhaps anything else on this planet....

[CatfatherB]

Hey Theanine, do you just eyeball 500 mgs.? It says to use a quarter teaspoon but since I can't use it? Just eyeball what looks like it would fit?

[guitartodd77]

Okay, I need help with this shilajit! I got it in the mail today, I had to pry the lid off of it, how in the hell do I measure out a quarter teaspoon when this stuff just sticks to my spoon?

I just eyeball a pea sized dose on the end of a butter knife. I dip the end of the butter knife into the material and scoop a little out and twirl the tail onto the knife kinda like using a fork to eat spaghetti.

I have a couple of gulps of hot water standing by. Once I have my pea sized glob on the end of my butter knife, i stir it into the hot water. It dissolves off of the knife completely within about 30-45 seconds of stirring.

I let it cool slightly, swirl the mixture around a bit to make sure it hasn't settled on the bottom and then down it. I then chase it with some tea or juice.