Palmitoylethanolamide - a novel OPIOID tolerance reducer

Post by **Theanine** » Sat Aug 10, 2019 8:09 am

GrannyJ62 wrote:I've been lurking and reading and I ordered and received my comfortMax today.I also posted in my fibromyalgia group for any info and not surprisingly only a couple of people of people have ever heard of it.And none had tried it.Way to many times prescription meds for a million other things are tried Gabapentin is basically the #1 med.Everyone seems afraid of anything a dr dosen't prescribe yet the side effects of these same drugs dont frighten them.We are such sheep sometimes. I know there are many great dr and many great prescription drugs .But Kratom and Weed have definitely shown me a much better way to deal with my chronic pain and CFS..
This is exciting to see that other things work so much better.I spent way to much of my life chained to prescription pain meds decades even.
Thanks again DoubleM friends for having this a place for honest talk. SO IM READY TO TAKE CONTROL of my life.
I just need to figure out how much to start with and I d be happy to share any information about how it helps.

Good job, Granny! I am so glad that it might be helping in your situation. Fibromyalgia is indeed a serious disorder with no real medical cure, only various treatments. Please, keep up the trial and report back your findings!

CatfatherB wrote:This is my first experience so far.....yesterday I probably over-did it cuz I was dosing with a plastic spoon from the break room, I forgot my pre-weighed doses at home. When I got home I got the PEA in the mail, took half a pill.

I took another half pill this morning and a half hour later, I dosed my usual weighed out dose of red M.D. from Sosa....BEST BURN OF THE WEEK it's too soon to know if it's the PEA yet cuz I've also took cats claw, turmeric and olive leaf extract all week.

Anybody else notice the difference? We may have found GOLD, guys, thanks to Theanine!!

Fantastic results, CatfatherB! So far, we have had some very positive results, which is encouraging. It is not everyday that we find an effective opioid tolerance reverser, and it sounds like, it may also be a potentiator. Although, I am yet cautious to label it as such. If indeed such is determined to be the case, this may very well be the single most effective adjunct to Kratom. Something akin to Agmatine, but without the incompatibility to Kratom.

Now, we only need to replicate our positive results. I would like to encourage everyone to chime in on this, for the group's benefit. Also, if anyone is on to the Honokiol formulation, it would be interesting to hear those results as well. Also, at some point down the road, we could do a summary survey of Palmitoylethanolamide's effects and responses.

Post by **Nic** » Sat Aug 10, 2019 8:21 am

I decided to give this a try also. I got my Comfort Max AM/PM yesterday. I started with half of a AM tablet before bed last night. I must say that last night was the best sleep I have had in a couple of years! I am a daily kratom user and my doses are around 7 grams. That’s just what works for me. My biggest complaint on kratom is that I usually wake up early and very irritable at times. This morning I slept in a little longer and I feel great this morning. I haven’t even took my morning dose yet! This stuff might really work well for me! Thanks for bringing this to the forum, Theanine. I will report back after a couple more days. I am going to continue using a half of an AM tab the next few nights.

Post by **instantKARMA** » Sat Aug 10, 2019 8:22 am

Well, Theanine, you certainly are going to be rolling in the dough with all
those commissions from comfortMax!

Ordered mine Thursday!

You have to be their best salesman EVER!

Post by **Theanine** » Sat Aug 10, 2019 8:34 am

Nic wrote:I decided to give this a try also. I got my Comfort Max AM/PM yesterday. I started with half of a AM tablet before bed last night. I must say that last night was the best sleep I have had in a couple of years! I am a daily kratom user and my doses are around 7 grams. That’s just what works for me. My biggest complaint on kratom is that I usually wake up early and very irritable at times. This morning I slept in a little longer and I feel great this morning. I haven’t even took my morning dose yet! This stuff might really work well for me! Thanks for bringing this to the forum, Theanine. I will report back after a couple more days. I am going to continue using a half of an AM tab the next few nights.

A very interesting observation. Perhaps, your evening dose of the Palmitoylethanolamide had reversed your tolerance enough to allow you to get that full night's of sleep. With kratom, insomnia is usually triggered by the intra dose withdrawals, which in turn cause insomnia, RLS, hot flashes, etc. to differing extents. They are the type of opioid withdrawals that one gets between their doses which usually means that the tolerance is quite high and there is a need for tolerance mitigation. When you wake up in the morning in a bad mood, it is the opioid withdrawal rearing its ugly head! If your tolerance is reduced, then the withdrawals are also correspondingly reduced. The amazing thing about it is that it worked for you almost immediately!

Would you consider lowering your Kratom dosage to 5 grams (2 teaspoons) instead of 7? Please, try it. I think you will get a LOT better result from your Kratom at that dose. With Palmitoylethanolamide, the tolerance reduction is almost immediate, so you could already be shaving off a gram per dose every day. When you get to 5 grams, you will notice MUCH better returns from Kratom. At that point, you may choose to go lower if you'd like, but you don't have to. I too was at around 8 grams, I am now down to 4 grams with BETTER results. I know that I could easily shave off another gram and still feel those effects!

Post by **Theanine** » Sat Aug 10, 2019 8:36 am

instantKARMA wrote:Well, Theanine, you certainly are going to be rolling in the dough with all
those commissions from comfortMax!
Ordered mine Thursday! You have to be their best salesman EVER!

I certainly wish that was the case! Honestly though, positive results and feedback from my fellow Kratomites is ALL the gratitude that I would ever need! Helping a fellow human in this world is its own reward.

Post by **Nic** » Sat Aug 10, 2019 8:53 am

This is really great. Less kratom, better results. Less withdrawal symptoms, better sleep. I am definitely going to bump my doses down the next few days and see what happens.

Post by **Lambeezy** » Sat Aug 10, 2019 9:01 am

The comfort max people are probably like why are all these people buying this shit all of a sudden lmao

Post by **Theanine** » Sat Aug 10, 2019 9:06 am

Nic wrote:This is really great. Less kratom, better results. Less withdrawal symptoms, better sleep. I am definitely going to bump my doses down the next few days and see what happens.

Precisely! Good summarization, Nic. This is precisely what we are trying to achieve here!

Lambeezy wrote:The comfort max people are probably like why are all these people buying this shit all of a sudden lmao

Indeed! Have you noticed that the reviews weren't so great? Mostly because some do not notice any results from it thinking it is just a placebo pill like most supplements, but WE do know that it is not a placebo pill, the joke is on them...

Post by **Lambeezy** » Sat Aug 10, 2019 9:23 am

Well theanine I think the people that left reviews are not using it for kratom tolerance reversal lol

Post by **Theanine** » Sat Aug 10, 2019 9:34 am

Lambeezy wrote:Well theanine I think the people that left reviews are not using it for kratom tolerance reversal lol

Indeed, but many still use it for better pain management as it modulates both opioid and cannabinoid receptors.

Of course, without something like Kratom in the mix, one would be hard pressed to notice any benefit from Palmitoylethanolamide, at least short term, and long term is not even in the picture. They take it a couple of times, do not get their perceived desired effect, and toss it in the garbage, this is where a negative review is born. "Oh this stuff aint nothin but placebo, I took it and felt the same, oh well" Oh, the humanity!

Post by **DrFappingston** » Sat Aug 10, 2019 9:42 am

Right then, so... I've been taking this PEA wonder-drug thing for 4 days now. I took the AM pill in the evening for 3 days, then last night, took the PM pill instead. I have taken it before and after my last kratom dose of the day, I have not noticed any diminished effects when I took it before taking kratom. Throughout this experiment I've also continued my DLPA and Cat's Claw each evening (I take after my last dose consistently). I've definitely seen improvements since starting to take the PEA. The Cat's Claw and DLPA seemed to be working, but slowly and mildly. I cannot conclusively report whether the benefits are coming mainly from the PEA or rather a combination of all 3 substances.

My kratom seems to be hitting harder for sure, the effects are also much more consistent. Whereas before, I would get varied results throughout the day and sometimes question if I even took the kratom at all. Now, every single time, I feel it come up and there's no question that it's working. This leads to more spaced out doses, consistently around 3-4 hours apart with little to no desire to redose before then. I generally rotate White Kaltim, White Banjo and Green Borneo through the work week which are 3 rather fast strains to help me fight through the brain fog and fatigue and get stuff done. My kratom is grabbing me by the hand and ripping me up out of the slump that I'm in, whereas before it was only a gentle nudge in the right direction at this point. I've been taking kratom daily since January without any breaks. All that I've done prior to this to combat tolerance is to cut my dose back down to 2g once I hit 5-6g doses and then climb back up again over the following 2-3 months. That seemed to be fairly effective for now, but I fear it wouldn't be sustainable forever. The subtle nature of kratom makes it difficult to really quantify how much more effective it is with the PEA regimen, but I think it's safe to say that it's working well, certainly better than anything else that I've tried.

This morning I woke up before my alarm, groggy as hell... I took my typical morning set of supplements and my 2g White Banjo and now I am wide awake. Normally this would only suffice to keep me awake enough to be congizant of time so that I'm ready for work when I need to leave. Currently, I feel like I could go for a brisk jog in the morning dew... or write a 5-paragraph forum post and I'm in a great mood to boot! I am not a morning person at all. Most people know not to try to talk to me within the first couple hours of the day because I'm just not fully here yet, but I am ready to go!

As for the PM pill... The extra added ingredient didn't seem to do anything for my wakefullness. Granted, I'm usually pretty resistant to non-prescription sleep aids in general, so I may not be the best judge for it's sedating properties. I've also been experimenting with nootropics, some of which are mild stimulants, so that very well could skew the results as well. I don't have much trouble sleeping normally, that is assuming I can get my brain to slow down... that usually is facilitated by taking a red vein kratom, typically Red Jongkong or Mystic Vampire.

Thank you Theanine for spearheading this research project and emparting your knowledge and hypotheses on the forum so that we may also benefit from the things that you find. I never would have guessed tolerance reducers could be this effective, and thus never really bothered searching for them. I figured the only method that would be truly effective would be to just stop taking kratom, or mix with S&V for a couple weeks to a month.

Post by **Theanine** » Sat Aug 10, 2019 10:58 am

Great post, DrFappingston, and great results too! Do take the AM and the PM formulation in alternating evenings, I would like to see if the Honokiol offers anything at all, we know that its not really added for sleep inducing purposes but rather as a synergist to the Palmitoylethanolamide, something to make it work more efficiently, but also something that might make one tired. As a result, it is only in the PM formula. This is not a sleep aid, so I doubt that they would put the Honokiol there for that purpose. Life Extension would unlikely to even implement the Honokiol if they did not believe it to be of some benefit. So, testing that component of this formulation is also important as it could provide even more benefits than then Palmitoylethanolamide by itself.

Another point about your dosages, DrFappingston. You have mentioned that you go as low as 2 grams per dose and then gradually increase it to 6 grams over a period of a few months. How about trying something different, getting your dose very low, like to 3 or 4 grams, and then keeping it there without further dose escalation.

Both reducing your dosages and keeping them there should be successfully achieved via multiple tolerance reducers and daily tapers. Also, please add Turmeric Extract standardized to 95% curcuminoids, 500 mg, at least once per day, after your kratom dose or perhaps even with it, even though I choose to take mine apart from Kratom. Keep up the good work, DrFappingston!

Post by **herbalhippie** » Sat Aug 10, 2019 11:08 am

I'd like to add here you should not take turmeric or curcumin if you have gallbladder issues. If you don't know you have gallbladder issues, and take curcumin, you'll find out if you have gallbladder issues soon enough. That was a very painful experience for me.

Post by **DrFappingston** » Sat Aug 10, 2019 11:31 am

Theanine wrote:Great post, DrFappingston, and great results too! Do take the AM and the PM formulation in alternating evenings, I would like to see if the Honokiol offers anything at all, we know that its not really added for sleep inducing purposes but rather as a synergist to the Palmitoylethanolamide, something to make it work more efficiently, but also something that might make one tired. As a result, it is only in the PM formula. This is not a sleep aid, so I doubt that they would put the Honokiol there for that purpose. Life Extension would unlikely to even implement the Honokiol if they did not believe it to be of some benefit. So, testing that component of this formulation is also important as it could provide even more benefits than then Palmitoylethanolamide by itself.

Another point about your dosages, DrFappingston. You have mentioned that you go as low as 2 grams per dose and then gradually increase it to 6 grams over a period of a few months. How about trying something different, getting your dose very low, like to 3 or 4 grams, and then keeping it there without further dose escalation.

Both reducing your dosages and keeping them there should be successfully achieved via multiple tolerance reducers and daily tapers. Also, please add Turmeric Extract standardized to 95% curcuminoids, 500 mg, at least once per day, after your kratom dose or perhaps even with it, even though I choose to take mine apart from Kratom. Keep up the good work, DrFappingston!

Sure, the Honokiol is not meant to be there for that purpose. It didn't seem to effect me that way, but I also do not see any benefits from OTC sleep aids either. I probably could have worded that better. I'm going to start alternating the AM and PM pills. I'm currently taking the whole 600mg with the ideology of an "attack dose", but will likely lower this to 300mg after a week or two.

If I feel the need to go up in dosage, then I will gradually make my way to the 3-4 gram doses... If I have to rise to 3-4 grams, I can only assume that trend would continue. Though, with this stuff, I'm not sure that I'll need to. I'd be beyond happy if I could just take 2g doses for the rest of time. I'm actually considering lowering it further, to 1g or 0.5 to see if I'm still getting benefits with the tolerance reduction.

I had been taking Turmeric and Bioperine in pill form once daily in the AM, but really didn't find much benefit from it. So when I ran out, I discontinued usage. I'd be interested in trying again, but with this current tolerance reduction regimen, I don't really think I would need anything else to keep things in check. Time will only tell if, after some time, I find that my doses aren't as effective despite the PEA, DLPA and Cat's Claw.

Post by **g0ldl10n** » Sun Aug 11, 2019 9:03 am

So I received my PEA yesterday morning, took 600mg tablet and I didn't notice any difference, but was not expecting to either from a single dose, so I'll continue on. That said, when I woke up this morning I was going through the motions and waiting for my Kratom tea to cool down, when all the sudden it hit me, most of the morning WD was gone. I'm still shocked and skeptical it wasn't just one of those things that coincidentally happened, but pleasantly surprised so far.

Post by **Theanine** » Sun Aug 11, 2019 9:24 am

A week and 100 posts later, I think it is apparent that there is definitely something to that Palmitoylethanolamide. I have reduced my tolerance significantly, so I will probably just cycle it from now on as I do not even need to go any further with my tolerance reduction. Never thought that I would say that. And most importantly, the Kratom magic is back! Just the same as it was during our honeymoon together. We were so happy and in love, never fought or argued, and now she is back! I should have just kept this thing a secret and sold it to kratomites as the Kratom Rejuvinator. Bring your Kratom magic back in one week for $20 for 7 magical beans

I mean, that's really all it took for me!

Also, there are no more withdrawals, not even the minimal one that were sometimes present before. My Kratom dose has gone down from 5 grams to 3.5 grams, I could easily drop another gram, but I won't, I need my Kratom! Another thing which I started to do differently is strain rotation and blends. I rotate about a dozen of strains now, will add another 8 or so to it in the next few days. My goal is to rotate around 20 to 30 completely different strains from a few different vendors and farmers. Right now, I am sticking with the Smiley Time Herbals in the first place and the Botanical Bunny as a runner up (close). STH selection is unbelievable and EVERY strain I got from them has been fire thus far, but it is the dry season.

Post by **herbalhippie** » Sun Aug 11, 2019 9:49 am

Here's my question. Do we share this knowledge with Reddit?

Post by **Theanine** » Sun Aug 11, 2019 10:00 am

herbalhippie wrote:Here's my question. Do we share this knowledge with Reddit?

NO WAY! It belongs to US! We keep it ALL to ourselves!

Post by **herbalhippie** » Sun Aug 11, 2019 10:10 am

Theanine wrote:
herbalhippie wrote:Here's my question. Do we share this knowledge with Reddit?
NO WAY! It belongs to US! We keep it ALL to ourselves!

Post by **Theanine** » Sun Aug 11, 2019 10:22 am

herbalhippie wrote:
Theanine wrote:
herbalhippie wrote:Here's my question. Do we share this knowledge with Reddit?
NO WAY! It belongs to US! We keep it ALL to ourselves!

Of course we share! With all who ask for it, the more the merrier!

Tonight, I will be trying that Honokiol at long last. It doesn't sound like it does much, but half of my pills have it so I might as well start using it. Who knows, it might offer some additional benefit, they had to have some reason to put it there. With time, I will be adding the Agmatine also, to see how they jive together. I would have done that already if I needed more tolerance reduction, but I honestly don't. The true test of it will be cold turkey test, that will show us what's what. No kratom for 24 hours is not something I want to do right now, especially with all of those fire strains just everywhere, and so much to test, so, so much. Whew, another 2 to 3 months of buying the dry season fare and testing it all while keeping my tolerance close to zero. That should provide for some accurate testing results too as the results of a burn are skewed if your tolerance is high. Damnit, I can't stop talking. The effect of Kratom is sociability and that effect has been recently boosted due to the overall tolerance reduction. As a result of that, here I am, chattering like a mad man!

Post by **herbalhippie** » Sun Aug 11, 2019 11:12 am

I'll make a post in the sub later linking to this thread.

Post by **herbalhippie** » Sun Aug 11, 2019 11:29 am

Theanine, how the heck did you find this? It's pretty darn obscure.

Post by **Theanine** » Sun Aug 11, 2019 12:33 pm

herbalhippie wrote:Theanine, how the heck did you find this? It's pretty darn obscure.

I think I just Googled: "morphine tolerance reduction" and went down the list of chemicals for that.

You know, opioid tolerance reduction is a very real medical concept which often goes completely ignored by modern clinicians. It is complicated and hard to navigate so instead of mitigating and managing pain, they simply give you more opioids, and take the patient to the point of full addiction. That's why there are so many pill addicts in the west, their doctors sold them out to the Pharma industry a long time ago....

Post by **herbalhippie** » Sun Aug 11, 2019 12:45 pm

Theanine wrote:
herbalhippie wrote:Theanine, how the heck did you find this? It's pretty darn obscure.
I think I just Googled: "morphine tolerance reduction" and went down the list of chemicals for that.

You know, opioid tolerance reduction is a very real medical concept which often goes completely ignored by modern clinicians. It is complicated and hard to navigate so instead of mitigating and managing pain, they simply give you more opioids, and take the patient to the point of full addiction. That's why there are so many pill addicts in the west, their doctors sold them out to the Pharma industry a long time ago....

Not just in the West. I think the Midwest might be worse. This is an excellent read if you're a reader and I think you probably are.

https://www.nytimes.com/2018/07/25/book ... risis.html

Post by **Lambeezy** » Sun Aug 11, 2019 12:55 pm

I already ordered mine. I don’t have prime because I’m a loser so mine will be here later this week. So is it really working for you guys or do you think there’s some placebo in there?

Post by **CatfatherB** » Sun Aug 11, 2019 1:08 pm

Lambeezy wrote:I already ordered mine. I don’t have prime because I’m a loser so mine will be here later this week. So is it really working for you guys or do you think there’s some placebo in there?

For me, it's a little too early to tell, I thought it may have potentiate my first dose yesterday when taking the PEA about half hour before my dose, it reminded me of the first time taking DXM before my dose, real intense and speedy.

I tried the other half of the PEA before my second dose without those results, so the first time could have been some synergy between the two, I'm gonna just take it after my last dose from now on.

Post by **Theanine** » Sun Aug 11, 2019 2:08 pm

herbalhippie wrote:
Theanine wrote:
herbalhippie wrote:Theanine, how the heck did you find this? It's pretty darn obscure.
I think I just Googled: "morphine tolerance reduction" and went down the list of chemicals for that.

You know, opioid tolerance reduction is a very real medical concept which often goes completely ignored by modern clinicians. It is complicated and hard to navigate so instead of mitigating and managing pain, they simply give you more opioids, and take the patient to the point of full addiction. That's why there are so many pill addicts in the west, their doctors sold them out to the Pharma industry a long time ago....

Not just in the West. I think the Midwest might be worse. This is an excellent read if you're a reader and I think you probably are.

https://www.nytimes.com/2018/07/25/book ... risis.html

Frankly, I am more of a Netflix guy!

I kid, I kid. This is indeed a good read, HH. I have seen that title around.

When I say Western medicine, what I mean is the entire modern medical industry, especially in the developed countries. The opioid epidemic are a direct fault of our beloved family physicians who for decades have been tirelessly working with the big Pharma to enslave their patients into this pharmaceutical bondage.

Giving more and more pain pills to anyone that beckons for it is NOT pain management, it is indeed drug dealing. Pain management involves tolerance mitigation and psychological addiction reduction techniques. NO ONE is doing that. They're just writing scripts and getting their clueless patients hooked for life! And not just on opioids. We have an antidepressant epidemic happening, but few are dying, so no one gives a hoot.

Post by **Kindashewantsto** » Sun Aug 11, 2019 2:10 pm

Thank you for this write up!

I am eager to try this, not only for the tolerance reducing effects but also because of my chronic pain and nerve pain, and inflammation. This seems like something I should have tried a long time ago!

Sitting here in intense pain all the damn time, I am so ready for anything to help. Kratom definitely helps me, but my pain is so constant and intense that it doesn't take it all away, and while it dulls it enough most of the time, it is still persistent.

I did some research and it doesn't seem like the ingredients will negatively impact my lupus - so I will be trying this ASAP!

Thanks again!

Post by **herbalhippie** » Sun Aug 11, 2019 2:16 pm

Just posted the link to this at r/kratomm

and then I deleted it and I'm going to repost it later because that stupid photo that ballz posted headed my post on Reddit.

Post by **Theanine** » Sun Aug 11, 2019 2:28 pm

herbalhippie wrote:Just posted the link to this at r/kratomm

and then I deleted it and I'm going to repost it later because that stupid photo that ballz posted headed my post on Reddit.

which photo is that?

Post by **g0ldl10n** » Sun Aug 11, 2019 2:28 pm

herbalhippie wrote:Just posted the link to this at r/kratomm

and then I deleted it and I'm going to repost it later because that stupid photo that ballz posted headed my post on Reddit.

Post by **Theanine** » Sun Aug 11, 2019 2:29 pm

Kindashewantsto wrote:Thank you for this write up!

I am eager to try this, not only for the tolerance reducing effects but also because of my chronic pain and nerve pain, and inflammation. This seems like something I should have tried a long time ago!

Sitting here in intense pain all the damn time, I am so ready for anything to help. Kratom definitely helps me, but my pain is so constant and intense that it doesn't take it all away, and while it dulls it enough most of the time, it is still persistent.

I did some research and it doesn't seem like the ingredients will negatively impact my lupus - so I will be trying this ASAP!

Thanks again!

No problemo, my friend. This is what we are here for after all! I am so sorry to hear that you're in so much chronic pain. It is very unfair to you, no one should be punished like this! Cruel and unusual, and you have done no wrong. Nature is such a cruel mistress. And yet, that mistress gifts us too, this plant of life is a nature's gift to us, unworthy humans.

In your situation, and for other people such as yourself, opioid tolerance mitigation is a question of life and death, or at the very least the quality of life itself. I am glad to see that you aren't taking it laying down and simply accepting of a river of poison that doctors are wanting to throw your way. Instead, you are choosing an alternative path, a path which requires more thinking and experimentation, but one that won't lead you to the absolutely guaranteed ruination that traditional opioids offer.

Do give DLPA, Cat's Claw, Turmeric extract, Agmatine, etc a look. There is much written about those and other tolerance reducers. As I said, for a chronic pain sufferer, especially something like what you have, Kratom and ways to keep it working indefinitely is paramount!

Kratom on!

Post by **herbalhippie** » Sun Aug 11, 2019 2:41 pm

Theanine wrote:
herbalhippie wrote:Just posted the link to this at r/kratomm

and then I deleted it and I'm going to repost it later because that stupid photo that ballz posted headed my post on Reddit.
which photo is that?

the one that I edited out of Ballz's post so I could link it to Reddit without it showing up.

Post by **Theanine** » Sun Aug 11, 2019 2:52 pm

herbalhippie wrote:
Theanine wrote:
herbalhippie wrote:Just posted the link to this at r/kratomm

and then I deleted it and I'm going to repost it later because that stupid photo that ballz posted headed my post on Reddit.
which photo is that?
the one that I edited out of Ballz's post so I could link it to Reddit without it showing up.

Good job! Link?

Whilst checking out the Reddit for HH's post, stumbled upon this article referencing some new research on how Mitragynine relates to the use of alcohol. It basically substitutes for it, which I have always contented. Which means that Kratom could be useful in the treatment of alcoholism. The ethanol cravings in mice are eliminated with the Mitragynine administration. I have personally seen many posts of people's experience with this phenomenon.

Another point is that apparently Mitragynine elevates Dopamine levels in the Nucleus Accumbens! Why is that important you ask. Well, Dopamine is a pleasure chemical in mammals, and the Nucleus Accumbens is a center in our brain responsible for pleasure and reward. You add it up. Placing the "pleasure" chemical into the "pleasure center" of our brains is the definition of euphoria!

Code: Select all

New kratom research from Malaysia helps explain why people who use kratom have less tendency to drink alcohol and increase their exercise levels.
Methanolic extract of Mitragyna speciosa Korth leaf inhibits ethanol seeking behaviour in mice: involvement of antidopaminergic mechanism. In the current study, the effect of methanolic extract of Mitragyna speciosa leaf (MMS) against the rewarding and reinforcing properties of ethanol using a mouse model of conditioned place preference (CPP) and runway model of drug self-administration was studied. Subsequently, the effect of MMS on dopamine level in the nucleus accumbens (NAc) of the mouse brain was further investigated. From the data obtained, MMS (50 and 75 mg/kg, p.o.) significantly reversed the ethanol-place preference in mice, which is similar to the effect observed in the reference drugs acamprosate (300 mg/kg, p.o.) and clozapine (1 mg/kg, p.o.) treatment groups in CPP test. Likewise, the escalating doses of ethanol-conditioned mice reduced the runtime to reach goal box, infers the positive reinforcing effects of alcohol. Interestingly, MMS (50, 75 and 100 mg/kg, p.o.) significantly prolonged the runtime in ethanol-conditioned mice. Besides, MMS (50 and 75 mg/kg, p.o.) and reference drugs; acamprosate (300 mg/kg, p.o.) and clozapine (1 mg/kg, p.o.) treated mice significantly decreased the alcohol-induced elevated dopamine level in the NAc region of the brain. Overall, this study provides first evidence that MMS inhibits ethanol seeking behaviour in mice. Based on these findings, we suggest that Mitragyna speciosa may well be utilized for novel drug development to combat alcohol dependence. Metab Brain Dis. 2019 Aug

https://www.reddit.com/r/kratom/comment ... s_explain/

Post by **BallzDeep9** » Sun Aug 11, 2019 9:13 pm

Hey wha happen to my classic Photo of Durk Pearson:

https://i.ytimg.com/vi/eVd_y5VAxEs/hqdefault.jpg

Post by **g0ldl10n** » Sun Aug 11, 2019 9:55 pm

BallzDeep9 wrote:Hey wha happen to my classic Photo of Durk Pearson: https://i.ytimg.com/vi/eVd_y5VAxEs/hqdefault.jpg

Post by **Theanine** » Mon Aug 12, 2019 2:43 am

BallzDeep9 wrote:Hey wha happen to my classic Photo of Durk Pearson: https://i.ytimg.com/vi/eVd_y5VAxEs/hqdefault.jpg

I miss the Durk!

Post by **herbalhippie** » Mon Aug 12, 2019 4:31 am

BallzDeep9 wrote:Hey wha happen to my classic Photo of Durk Pearson: https://i.ytimg.com/vi/eVd_y5VAxEs/hqdefault.jpg

Sorry, Ballz. I had to make it go away. For the sake of my Reddit post.

Post by **Patchgarden** » Mon Aug 12, 2019 7:31 am

So I am on day four of talking PEA at night two hours after my last dose. I can say that I have been sleeping better then I have in six months. I am going to try and take my dose in the morning in stead of at night. I feel like I feel so much better after I take my nightly dose of kratom and PEA together. This experiment is tricky because I am going through a flare up which naturally throws my body and all over the place. I will switch it up tomorrow and see if I can extend this good feeling throughout the day.

Post by **Lambeezy** » Mon Aug 12, 2019 11:39 am

Has anyone noticed magnesium blocking some of the effects of kratom for them?