7-OH and Tolerance

[anonk]

Curious to hear what everyone's experience with 7-OH and tolerance is. This idea that there is no cross-tolerance is just not the case, Mitragynine gets metabolized into 7-OH at a rate of 23%, also if you look at both molecules you'll notice they are exactly the same except for the hydroxyl group. I've only used a total of 3 times (once every 7 days) and found that at first my tolerance would rebound faster than with MIT extracts (shorter half-life) however, each use would compound and get exponentially worse. By the third time plain leaf would have zero effect for 3 days and a full 7 days to return back to baseline. I also find that I'm significantly depressed the following days after, something that I've never experienced from MIT extracts. My final verdict: I firmly believe there is no "free lunch" in the dopamine department, the effect that 7-OH gives is just too good and ultimately not sustainable.

[GreenAnimal]

I’ve never tried pure 7oh, I didn’t even know that was a thing. But I totally agree with you that there would be no cross tolerance. Scientifically, that just wouldn’t make sense because as you stated the mit gets converted to 7oh.

As far as the mood crash, I have experienced that with plain leaf t-breaks. I’ll just feel really down and moody for a couple days.

[BookofEnoch1914]

Curious to hear what everyone's experience with 7-OH and tolerance is. This idea that there is no cross-tolerance is just not the case, Mitragynine gets metabolized into 7-OH at a rate of 23%, also if you look at both molecules you'll notice they are exactly the same except for the hydroxyl group. I've only used a total of 3 times (once every 7 days) and found that at first my tolerance would rebound faster than with MIT extracts (shorter half-life) however, each use would compound and get exponentially worse. By the third time plain leaf would have zero effect for 3 days and a full 7 days to return back to baseline. I also find that I'm significantly depressed the following days after, something that I've never experienced from MIT extracts. My final verdict: I firmly believe there is no "free lunch" in the dopamine department, the effect that 7-OH gives is just too good and ultimately not sustainable.

I couldn't have written this better if I tried, this mirrors my same experiences almost to a T. I had been experimenting with 7Ohm for over a year, before the "Explosion" as I call it. I found that even using under 15mgs 7Ohm ONCE a week completely negated Plain Leaf's AND Mid Range Mit extract's effects the rest of the week. And to top it off I found myself dreaming about 7Oh during the sleep hours, and craving it during my waking hours.it took me almost 3 weeks with ZERO intake for Leaf to start hitting again. Also, it's effects for me are so short lived and come with a dopamine Crash, unlike other opioids at least for me. This leads to a STRONG Compulsion to Re-Dose which will only further compound the tolerance issues. I have used a myriad of opioids in my time and I have NEVER seen Tolerance build as fast as 7OH. It's truly astounding. Unless you are dealing with untreated broken bones or literally crippling pain that doctors refuse to treat.....I would recommend staying away. It will nullify the effects of this plant that we love. It definitely did for me. And this was from a ONCE a week user.

[boureka]

A little background would be helpful here for the likes of me. Are there 7OH products out there? Or are you loosely using the term to refer to leaf?

[anonk]

A little background would be helpful here for the likes of me. Are there 7OH products out there? Or are you loosely using the term to refer to leaf?

You walk into any head shop now and there's 20+ brands of tablets and shots now but the best place to go is https://www.kratomdistro.com/ for the cheapest tablets.

[boureka]

A little background would be helpful here for the likes of me. Are there 7OH products out there? Or are you loosely using the term to refer to leaf?

You walk into any head shop now and there's 20+ brands of tablets and shots now but the best place to go is https://www.kratomdistro.com/ for the cheapest tablets.

The last time I was in a head shop...was...forever ago. My first kratom was quality small batch and I've never bought kratom other than online from good vendors...so I have no idea what's out there in the gas stations and head shops. Didn't know they sold 7OH products. I've never experienced anything other than leaf and have an instinctive fear of extracts and the like. Thanks for the info!

[Csharpe]

For the last month and a half I’ve taken one 14mg tablet on Saturdays and Sundays, if I’m off work. Hadn’t had any issues with regular kratom hitting after those days, funny enough I usually get the best effects off my normal kratom dose the Monday after I take 7-OH. The effects are great and for me last hours longer than normal kratom but I agree there is a heavy feeling on the come down. It’s definitely strong and enjoyable but I don’t see how people take it every day, too heavy, better as a treat to me. Yet go on some Reddit subs and you’ve got people taking 100-200 mg every day.. freaking wild to me lol

[GreenAnimal]

A little background would be helpful here for the likes of me. Are there 7OH products out there? Or are you loosely using the term to refer to leaf?

You walk into any head shop now and there's 20+ brands of tablets and shots now but the best place to go is https://www.kratomdistro.com/ for the cheapest tablets.

The last time I was in a head shop...was...forever ago. My first kratom was quality small batch and I've never bought kratom other than online from good vendors...so I have no idea what's out there in the gas stations and head shops. Didn't know they sold 7OH products. I've never experienced anything other than leaf and have an instinctive fear of extracts and the like. Thanks for the info!

I usually don’t mess with extracts either. But this sounds really tempting. I don’t want to mess up my tolerance though. It’s a dilemma haha.

[GreenAnimal]

For the last month and a half I’ve taken one 14mg tablet on Saturdays and Sundays, if I’m off work. Hadn’t had any issues with regular kratom hitting after those days, funny enough I usually get the best effects off my normal kratom dose the Monday after I take 7-OH. The effects are great and for me last hours longer than normal kratom but I agree there is a heavy feeling on the come down. It’s definitely strong and enjoyable but I don’t see how people take it every day, too heavy, better as a treat to me. Yet go on some Reddit subs and you’ve got people taking 100-200 mg every day.. freaking wild to me lol

Great info, thanks! Once a week sounds perfect and sounds like you’re using it responsibly. Good to hear you still get effects from regular powder. And I agree that 100-200mg is freaking bonkers. These types always end up being the people that make the rest of us look bad.

[Kelleytoons]

Hopefully Mr. B will chime in here - it was his experience with it that got me to try it.

And now I wouldn't be without it. However, I keep my doses low - usually 1/4 a table (which is 20mg so that's about 5mg) along with 2grams or less of kratom, at night (where I need it the most). I have done UP to 1/2 a tablet but I would not recommend more, nor would I do it more than 4 or 5 times a week (the 1/4 tablet, that is). So perhaps ONE or two tablets a week at the most.

Luckily it's pretty expensive, so that tends to tamp down the usage (I bought 150 tablets, which should last me a year or so). When I don't use it (when I take my kratom alone) it seems to have no affect on my tolerance - it's a completely different experience that is SO different from kratom I doubt there is any overlap at all.

[ivanquamay]

Weird the variation in tolerance effects. That makes me nervous.

[GreenAnimal]

it's a completely different experience that is SO different from kratom I doubt there is any overlap at all.

Interesting… how does the experience vary? I’m still really tempted here. Especially if it won’t mess with my tolerance.

[ivanquamay]

it's a completely different experience that is SO different from kratom I doubt there is any overlap at all.

Interesting… how does the experience vary? I’m still really tempted here. Especially if it won’t mess with my tolerance.

I haven't tried pure 7OHM, but I assume it's straight downtown.

[Kelleytoons]

Interesting… how does the experience vary? I’m still really tempted here. Especially if it won’t mess with my tolerance.

It's worth a try. It's hard to describe what it does, but it's certainly soothing and feely-goodly <g>. Just keep your dose low (5gm is likely a good point). Cost will most likely help with that <g>.

[BookofEnoch1914]

https://www.reddit.com/r/quitting7oh/s/UsT0DSpCOA

[Kelleytoons]

LOL - yeah, and I can post similar reddits (about the worst source of info ever) that show the same thing about kratom.

Look - ANYTHING can be addictive. And you, yourself, know best what is good for you. If you think you will have an issue with ANYTHING then don't use it. Don't use kratom, don't even use aspirin (the worse of all the drugs). Just take care.

(Plus - don't take more of anything. I mean that. ESPECIALLY kratom. Some of you folks dosing with more than 3 grams of kratom need to reexamine what the heck you are doing).

[anonk]

it's a completely different experience that is SO different from kratom I doubt there is any overlap at all.

Interesting… how does the experience vary? I’m still really tempted here. Especially if it won’t mess with my tolerance.

Oh It will definitely mess your tolerance up, it's like saying morphine doesn't mess up my codeine tolerance. Mitragynine is metabolized in the liver to 7-OH, you are just skipping this step, 7-OH has a 10 fold higher binding affinity than mitragynine.