After researching for a many months I have found the following to effectively boost kratom allowing the kratom user to lower dosage and even take less with greater effects. Some even level out the effects from certain strains. Most of the info in this guide will be copied info and collaboration if testimonial data from the web, studies and social media.
The safest natural potententiators(boosters) of kratom according to Kratomites across forums and social media are:
Grapefruit juice: also works on metabolism and boosts opioids allowing the user to take less. More than 16oz is required for desired effects. About two cups. Pulp organic works better than from concentrate.
Black Pepper: believe it or not pepper effects metabolism and boost effects of many opiates and opioids including opioid like substances like kratom and akuamma seeds. a spoon full of Pepper is recommended to be toss and washed before the kratom.
Blue Lotus: it can boost the euphoric feeling of many substances and some users feel mdma like effects when mixed with kratom. 50x extract of Blue lotus flower. You will need around 5-15g depending on the person. Start at 3g and work your way up from there.
Natural and botanical potententiators of kratom a further explanation:
White Grapefruit Juice:
contains three ingredients that clog the CYP450 set. However, it doesn't clog CYP2D6 too well, which is the main one for most opiates/opiods. It does strongly 'clog' CYP3A4 though and although that's almost an 'auxillary' enzyme for alot of opiates, it definitely helps out. Any grocery store and you should be able to get a nice big bottle of 100% white grapefruit juice from concentrate. If organic is possible get that since I find pulp 100% is also great for this.
An important thing to note for the grapefruit juice is the percentage of juice. A lot of companies make "White Grapefruit Juice" that is basically water, corn syrup, and like 10% juice, you don't want that at all. Look in the ingredients list, and make sure the only juice in there is white grapefruit, preferably from concentrate. Nutritionally, juices from concentrate are usually not as good. However, for one reason or another, grapefruit juice from concentrate can contain 25%-40% MORE naringin, bergamottin and dihydroxybergamottin; the three enzyme inhibitors present in white grapefruit.
Grapefruit Juice: Ruby Red GFJ
It is an optimal potentiator and is used commonly in routine life by the kratom users. The users recommend the combination of kratom with grapefruit juice so that it can be easily swallowed and the bitter taste is alleviated.
The users use this method for prolonged motivation to use kratom and get help in reducing the bitterness, but the actual benefit with its combination is that the benefits endured longer with this consumption method. Grapefruit peels also contribute to accomplishing the same results.
The grapefruit juice enhances the kratom effects, but the chemical of grapefruit juice influences the digestive enzymes linking with the metabolism of kratom alkaloids, doubling the strength for the treatment of pain or anxiety.
Turmeric:
turmeric is a type of ordinary spice grown in India. It is the perfect spice which surpasses the other foods which help in intensifying the kratom potency. The turmeric produces an encompassing intensification of various physical effects produced by kratom along with the extension of results.
The users claim turmeric as an active boost for kratom effects.
Cayenne Pepper:
it is an especial hot pepper which helps in detoxing and cleansing the body. It aids in increasing the kratom’s potency and effects. Users prefer mixing the cayenne pepper with dry kratom powder. The pepper has an intense spiciness so use it in meager amounts.
The cayenne pepper is a powerful compound which helps in producing saliva for digestion, aids in weight loss and helps in relieving the joint pain with the use of kratom.
The combination of black pepper with the kratom helps in increasing the kratom’s potency along with it lowers the tolerance level.
Watercress:
it is an ultra-hydrating lettuce which significantly potentiates the kratom effects. It is an effective natural food with a powerful mineral that potentiates the effects of kratom.
Supplements that help in potentiating the Kratom effects
These supplements include:
Agmatine:supplement
it is also termed as Guanidine, which aids in improving the ability of kratom to treat the opiate addiction. Use moderation! Can increase tolerance over time.
Agmatine is also natural, it's not a drug, it's the natural breakdown product of Arginine, an amino acid. Agmatine is found naturally in the human body as well.
Agmatine works by acting on nitiric oxide synthase to modulate excess nitric oxide signalling. This is the mechanism most likely resulting in Agmatine's potentiation and tolerance reduction of opioids.
Agmatine also acts as a mild NMDAr antagonist, a very strong Imidazoline agonist, also modulates the serotonin, cholinergic, and adrenergic systems. Nicknamed "Clonidine Displacing Substance" for a reason. It binds so strongly to Imidazoline and Adrenergic receptors is will nock Clonidine off the receptor.
Examine has a really nice overview of Agmatine:
https://examine.com/supplements/agmatine/
Valerian root: the root helps in a peaceful sleep and enhances the relaxing effects of various kratom strains.
Caffeine: the coffee has an enough amount of caffeine which helps in reducing the lethargy effects, that is a mild side effect of different kratom strains. The combination of caffeine with kratom increases the alertness, energy, and focus.
Cat’s claw: this herb has alkaloids which are like kratom. If you take cat’s claw along with kratom, it will intensify the effects and potency of any kratom strain. This woody vine is found in Central and South America. It is scientifically referred to as “Uncaria Tomentosa,” contains the alkaloids which synergize the kratom alkaloids for increasing the duration of kratom’s effects.
Cats's claw description: isn't an opioid antagonist like some think. It is an NMDA antagonist (among having other properties).
NMDA antagonists have been shown to decrease the addictiveness of many addictive drugs such as opiates and amphetamines. There is also evidence that they can prevent the build up of tolerances and even reduce tolerance. And some people claim that they potentiate opiates and opioids.
But cat's claw is also a mild MAO-B inhibitor. There seems to be mixed results about combining kratom and MAO-A inhibitors (like Syrian Rue), but I have never read any negative reports aboutcombining kratom and MAO-B inhibitors.
The worries about kratom and MAO-A inhibitors stems from the serotonergic actions of kratom. Kratom possibly raises levels of serotonin, which is metabolized by MAO-A. Inhibiting this enzyme can therefore lead to uncomfortably high levels of serotonin and possibly serotonin toxicity.
MAO-B does not affect serotonin, so serotonin is unlikely to be a problem. And MAO-B inhibitors tend to be safer than MAO-A inhibitors as far as I can tell. But it is possible that an MAO-B inhibitor could interact with some of the various compounds in kratom. There are many unstudied compounds in kratom, and many of the compounds in kratom are monoamines or could otherwise be potentiated by an MAOI.
This means that cat's claw could possibly cause a negative reaction if combined with kratom. Or it may increase its potency. Either way, be careful and start with lower doses of both if you decide to give it a try.
Use moderation and caution with cats claw
"The below quote on black pepper is from: u/herbalhippie* Thank you.
Black Pepper:
How do the potentiators work?The active ingredient in pepper that potentiates many things is bioperine. It's a CYP3A4 inhibitor, it inhibits metabolism of opiates/opioids and many other medications. Black pepper contains roughly 5-9% bioperine. You can buy bioperine as a supplement, I have a bottle but I've never tried it.
I took omeprazole for a couple years every day, that seems to potentiate kratom as well.
According to the science, how do the common foods, herbs and botanical supplements potentiate kratom? The foods which have the potentiating component works by regulating the metabolism, mainly focusing on the cytochrome P-450 enzyme. The alkaloids in kratom undergo breakdown along with the removal process due to the help of cytochrome P-450 enzyme within the system. Foods which result in reducing the enzyme function helps in extending the kratom effects.
There are different OTC drugs and other assortment of things that inhibit your enzymes. Which essentially means they clogs the enzymes that metabolize opiates\opioids and clear them out of the body, which results them staying in your body way, way, way longer, and a way more happy kratomite. Also, blood plasma levels of opiates have been shown to vastly higher when the CYP450 set is strongly inhibited; meaning their is a higher peak, and it lasts longer. This of course applies to mitragynine, 7-hydroxymitragynine and 9-hydroxycorynantheidine as well since they are kratoms mu agonists which bind almost the same way as opioids to the same receptors. What the clinging of enzymes dies is allow the mitragynine and indoles/oxindoles of mitragynine to attach to the opioid receptor sites within the GI tract, CNS and neuron wall more abundantly than if those enzymes killed most of the kratom.
Drugs which potentiate the effects of Kratom
The drugs which potentiate the effects of kratom leads to the inhibition of kratom’s metabolism in the digestive system, especially in the liver. However, these drugs result in dangerous interaction with liver’s microsomal enzyme system specifically CYP3A4 and CYP2D6.
These drugs lead to tolerance and adverse effects with a high dosage of kratom or more than the recommended amount. These drugs include:
Tianeptine:
it enhances the euphoric consequences by the consumption of kratom.
Diphenhydramine:
it enhances the sedative effects of kratom.
Acetaminophen:
it increases the pain-relieving and analgesic effects of kratom. Use caution it is very toxic at high doses.
Magnesium:
Magnesium is a popular supplement with potentiating effects. It serves in reducing the tolerance if used for long-term, allowing you to use less amount of kratom with time.
Magnesium helps in relieving constipation but will worsen diarrhea. This drug results in adverse effects on patients who are in self-weaning process with the use of opiates.
Phenibut:
It is a substance which is available as a supplement and a prescription drug. It helps in treating multiple ailments example, anxiety, PTSD (post-traumatic stress disorder), and insomnia. It helps in potentiating the effects of kratom for relaxation. Note: it us very addicting, use with moderation and care. Do your research before using this.
Cimetidine or Tagamet:
It amplifies the kratom effects. It is an over-the-counter drug which helps in treating the gastric ailments along with the heartburn. The recommended dosage of this medication is effective to potentiate the kratom effects.
Note: Do not take more than one herb or supplement with your kratom experience. Users claim that one additive is more than enough for achieving the maximum results with kratom, it is not necessary to add more than one additive as it will not potentiate the benefits. Do your own research on drugs that are listed, they can have dangerous effects and require care when using this.
Benadryl (diphenhydramine HCl) and CPM (chlorpheniramine maleate) are both over-the-counter anti-histamines that increase the analgesic and euphoric properties of opiates to some extent. They also help cut down on the ope-itch. In addition, these they also slightly inhibit subset CYP2D6.
DXM (Dextromethorphan HBr, Robitussin, Zicam, etc.) Although it doesn't inhibit the CYP450 set to any appreciable extent, it does contribute to analgesia and euphoria for all major opiates. Also, it has been shown to prevent the build up of tolerance! 30mg of DXM a good half hour or so before dosing will definitely slow any tolerance build up if you use this method every time. And with opiates, that's a very big deal as many of you may know.
Please do your own research on each of these drugs before using it combining them. DXM can be very dangerous and us worth mentioning that it is a controlled substance. It may be used as an OTC but that doesn't mean taking large amounts and combining with kratom or opioids is safe, last thing we want is to give the FDA more deaths to boast around.
Verdict
The combination of potentiators with kratom strain results in a long duration of effects. It allows the user to get through with adequate doses feeling more stimulated, relaxed and peaceful. With potentiators, the effects of kratom are more powerful and heightened.
If I made any mistakes please let me know, also if I missed anything that could be considered a good potententiator for kratom let me know so I can add to the list helping to make it a more comprehensive list of potententiators for kratom.
Use moderation, be safe and as always test before you ingest just like i always say about research chemicals or any substance. Most of all have fun and enjoy the many benefits kratom has to offer.
Sincerely, PsilocybeFanaticis.
